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Study identifier: NCT02311933 Synced from ClinicalTrials.gov · August 06, 2026
● Study status: Active Not Recruiting

Tamoxifen Citrate or Z-Endoxifen Hydrochloride in Treating Patients With Locally Advanced or Metastatic, Estrogen Receptor-Positive, HER2-Negative Breast Cancer

Condition: Recurrent Breast Carcinoma · Stage III Breast Cancer AJCC v7 · Stage IIIA Breast Cancer AJCC v7  ·  Sponsor: National Cancer Institute (NCI)

PhasePhase 2
Planned participants81
Who can joinFemale, 18 Years to no upper limit
Healthy volunteersNo

About this study

This randomized phase II trial studies how well tamoxifen citrate works compared with z-endoxifen hydrochloride in treating patients with breast cancer that has spread to nearby tissue or lymph nodes or other parts of the body and has estrogen receptors but not human epidermal growth factor receptor 2 (HER2) receptors on the surface of its cells. Estrogen can cause the growth of tumor cells. Hormone therapy using tamoxifen citrate or z-endoxifen hydrochloride may fight breast cancer by lowering the amount of estrogen the body makes. It is not yet known whether tamoxifen citrate or z-endoxifen hydrochloride is more effective in treating patients with breast cancer.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (559)

Southern Cancer Center PC-ProvidenceMobile, Alabama, United States
Anchorage Associates in Radiation MedicineAnchorage, Alaska, United States
Anchorage Radiation Therapy CenterAnchorage, Alaska, United States
Alaska Breast Care and Surgery LLCAnchorage, Alaska, United States
Alaska Oncology and Hematology LLCAnchorage, Alaska, United States
Alaska Regional HospitalAnchorage, Alaska, United States
Alaska Women's Cancer CareAnchorage, Alaska, United States
Anchorage Oncology CentreAnchorage, Alaska, United States
Katmai Oncology GroupAnchorage, Alaska, United States
Providence Alaska Medical CenterAnchorage, Alaska, United States
Fairbanks Memorial HospitalFairbanks, Alaska, United States
Mayo Clinic Hospital in ArizonaPhoenix, Arizona, United States

+ 547 more locations — full list on the registry record.

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