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Study identifier: NCT00381680 Synced from ClinicalTrials.gov · August 06, 2026
● Study status: Completed

Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia

Condition: B-cell Childhood Acute Lymphoblastic Leukemia · L1 Childhood Acute Lymphoblastic Leukemia · L2 Childhood Acute Lymphoblastic Leukemia  ·  Sponsor: Children's Oncology Group

PhasePhase 3
Planned participants275
Who can joinAll sexes, 1 Year to 29 Years
Healthy volunteersNo

About this study

This randomized phase III trial is studying low-dose vincristine to see how well it works compared with high-dose vincristine when given together with different combination chemotherapy regimens in treating young patients with intermediate-risk relapsed B-cell acute lymphoblastic leukemia. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) and giving the drugs in different ways and different doses may kill more cancer cells..

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

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Locations (173)

Children's Hospital of AlabamaBirmingham, Alabama, United States
University of Alabama at BirminghamBirmingham, Alabama, United States
Phoenix Childrens HospitalPhoenix, Arizona, United States
University of Arizona Health Sciences CenterTucson, Arizona, United States
University of Arkansas for Medical SciencesLittle Rock, Arkansas, United States
Children's Oncology GroupArcadia, California, United States
Southern California Permanente Medical GroupDowney, California, United States
City of Hope Medical CenterDuarte, California, United States
Loma Linda University Medical CenterLoma Linda, California, United States
Miller Children's HospitalLong Beach, California, United States
Children's Hospital Los AngelesLos Angeles, California, United States
Cedars-Sinai Medical CenterLos Angeles, California, United States

+ 161 more locations — full list on the registry record.

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