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Study identifier: NCT00365105 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Completed

Zoledronate, Vitamin D, and Calcium With or Without Strontium 89 or Samarium 153 in Preventing or Delaying Bone Problems in Patients With Bone Metastases From Prostate Cancer, Lung Cancer, or Breast Cancer

Condition: Breast Cancer · Lung Cancer · Metastatic Cancer  ·  Sponsor: Radiation Therapy Oncology Group

PhasePhase 3
Planned participants261
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

RATIONALE: Zoledronate, vitamin D and calcium may prevent or delay bone pain and other symptoms caused by bone metastases. It is not yet known whether giving zoledronate together with vitamin D and calcium is more effective with or without strontium 89 or samarium 153 in treating patients with bone metastases from prostate cancer, lung cancer, or breast cancer. PURPOSE: This randomized phase III trial is studying zoledronate, vitamin D, and calcium to see how well they work compared to zoledronate, vitamin D, calcium, and either strontium 89 or samarium 153 in preventing or delaying bone problems in patients with bone metastases from prostate cancer, lung cancer, or breast cancer.

This description comes directly from the study's public registry record.

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Locations (147)

Providence Cancer Center at Providence HospitalMobile, Alabama, United States
Roy and Patricia Disney Family Cancer Center at Providence Saint Joseph Medical CenterBurbank, California, United States
Mercy Cancer Center at Mercy San Juan Medical CenterCarmichael, California, United States
USC/Norris Comprehensive Cancer Center and HospitalLos Angeles, California, United States
Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical CenterPomona, California, United States
Radiation Oncology Center - RosevilleRoseville, California, United States
Radiological Associates of Sacramento Medical Group, IncorporatedSacramento, California, United States
General Robert Huyser Cancer Center at David Grant Medical CenterTravis Air Force Base, California, United States
Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross HospitalFort Lauderdale, Florida, United States
Baptist Cancer Institute - JacksonvilleJacksonville, Florida, United States
Integrated Community Oncology Network at Southside Cancer CenterJacksonville, Florida, United States
Baptist Medical Center SouthJacksonville, Florida, United States

+ 135 more locations — full list on the registry record.

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