Condition: Colorectal Cancer · Sponsor: Alliance for Clinical Trials in Oncology
Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.
PURPOSE: This randomized phase III trial is studying cetuximab and/or bevacizumab when given together with combination chemotherapy to compare how well they work in treating patients with metastatic colorectal cancer. RATIONALE: Monoclonal antibodies, such as cetuximab and bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Cetuximab may also stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. Drugs used in chemotherapy, such as fluorouracil, leucovorin, oxaliplatin, and irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving monoclonal antibodies together with combination chemotherapy may kill more tumor cells. It is not yet known whether combination chemotherapy is more effective with cetuximab and/or bevacizumab in treating patients with colorectal cancer.
This description comes directly from the study's public registry record.
No contact information is available for this study as per the public registry record.
Always discuss trial participation with your own doctor first.
| Providence Cancer Center at Providence Hospital | Mobile, Alabama, United States | — |
| Alaska Regional Hospital Cancer Center | Anchorage, Alaska, United States | — |
| Providence Cancer Center | Anchorage, Alaska, United States | — |
| Hembree Mercy Cancer Center at St. Edward Mercy Medical Center | Fort Smith, Arkansas, United States | — |
| NEA Medical Center - Stadium Boulevard | Jonesboro, Arkansas, United States | — |
| Roy and Patricia Disney Family Cancer Center at Providence Saint Joseph Medical Center | Burbank, California, United States | — |
| East Bay Radiation Oncology Center | Castro Valley, California, United States | — |
| Valley Medical Oncology Consultants - Castro Valley | Castro Valley, California, United States | — |
| North Bay Cancer Center | Fairfield, California, United States | — |
| Kaiser Permanente - Fremont | Fremont, California, United States | — |
| Valley Medical Oncology | Fremont, California, United States | — |
| Glendale Memorial Hospital Comprehensive Cancer Center | Glendale, California, United States | — |
+ 671 more locations — full list on the registry record.
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