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Study identifier: NCT00265850 Synced from ClinicalTrials.gov · August 07, 2026
● Study status: Completed

Cetuximab and/or Bevacizumab Combined With Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer

Condition: Colorectal Cancer  ·  Sponsor: Alliance for Clinical Trials in Oncology

PhasePhase 3
Planned participants2334
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

Sponsor, CRO or site team? See where this study is running → — listed sites, countries and recruiting context. Everything below is written for patients and caregivers.

About this study

PURPOSE: This randomized phase III trial is studying cetuximab and/or bevacizumab when given together with combination chemotherapy to compare how well they work in treating patients with metastatic colorectal cancer. RATIONALE: Monoclonal antibodies, such as cetuximab and bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Cetuximab may also stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. Drugs used in chemotherapy, such as fluorouracil, leucovorin, oxaliplatin, and irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving monoclonal antibodies together with combination chemotherapy may kill more tumor cells. It is not yet known whether combination chemotherapy is more effective with cetuximab and/or bevacizumab in treating patients with colorectal cancer.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (683)

Providence Cancer Center at Providence HospitalMobile, Alabama, United States
Alaska Regional Hospital Cancer CenterAnchorage, Alaska, United States
Providence Cancer CenterAnchorage, Alaska, United States
Hembree Mercy Cancer Center at St. Edward Mercy Medical CenterFort Smith, Arkansas, United States
NEA Medical Center - Stadium BoulevardJonesboro, Arkansas, United States
Roy and Patricia Disney Family Cancer Center at Providence Saint Joseph Medical CenterBurbank, California, United States
East Bay Radiation Oncology CenterCastro Valley, California, United States
Valley Medical Oncology Consultants - Castro ValleyCastro Valley, California, United States
North Bay Cancer CenterFairfield, California, United States
Kaiser Permanente - FremontFremont, California, United States
Valley Medical OncologyFremont, California, United States
Glendale Memorial Hospital Comprehensive Cancer CenterGlendale, California, United States

+ 671 more locations — full list on the registry record.

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