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Condition: Severe Mental Disorder Synced from ClinicalTrials.gov · July 28, 2026

Recruiting studies: Severe Mental Disorder

Studies currently listed as recruiting on the public registry for this search term. Each page explains the study in plain language, with locations and the study team's contact details. Clinicians: generate a printable list for your patient →

Propranolol for Aggression, Self-Injury, and Severe Disruptive Behavior in Adolescents and Adults With Autism
Phase 2 · 2 location(s) · Jeremy Veenstra-vanderweele · NCT07091279Validation of the CIDI 5.0 Against the SCID-5 for Lifetime Mental Disorders
Phase N/A · 1 location(s) · The University of Hong Kong · NCT07604753Neural Response to Inflammatory Challenge in Major Depressive Disorder
Phase 1/Phase 2 · 1 location(s) · Laureate Institute for Brain Research, Inc. · NCT04751331Brief Trial of ACT-i for Adults With Chronic Insomnia
NA · 1 location(s) · Babes-Bolyai University · NCT07048600A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressi
Phase 3 · 60 location(s) · Neurocrine Biosciences · NCT07196501Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients
Phase 3 · 68 location(s) · Intra-Cellular Therapies, Inc. · NCT06372964Intravenous Ketamine for Treatment-Resistant Depression
Phase 2 · 1 location(s) · Mayo Clinic · NCT06668571Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolesce
NA · 2 location(s) · University of Alabama at Birmingham · NCT05437588Biomarkers of Depression and Treatment Response
NA · 1 location(s) · University of California, San Francisco · NCT04581902Italian Adaptation and Validation of Functional and Behavioural Scales for Subjective Cognitive Decline, Mild Cognitive
Phase N/A · 1 location(s) · Casa di Cura IGEA · NCT06701630Apnea, Stroke and Incident Cardiovascular Events
Phase N/A · 1 location(s) · University Hospital, Grenoble · NCT04399200Amygdala Neurofeedback for Depression - Large Scale Clinical Trial
NA · 1 location(s) · Kymberly Young · NCT05703256fNIRS for Disorders of Consciousness
Phase N/A · 1 location(s) · University of California, Los Angeles · NCT07485361Social Cognition in Severe Alcohol Use Disorder
NA · 1 location(s) · CHU de Reims · NCT07464613Psychiatric Multi-omics and Neuroimaging Project
Phase N/A · 1 location(s) · mingjun Zhong · NCT06580860Prediction of REsponse to Depression Interventions (Accelerated rTMS) Using Clinical and TD-fNIRS Measurements
Phase N/A · 2 location(s) · Kernel · NCT07294924Effect of Psychobiotics With Standard Antiddepressants in Treatment of Major Depressive Disorder
NA · 1 location(s) · Dr Sadia yasir · NCT07691749Risk of Major Adverse Cardiovascular Events for Naldemedine & Other Medications for Opioid Induced Constipation
Phase N/A · 1 location(s) · BioDelivery Sciences International · NCT03720613Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Ketamine
EARLY_Phase 1 · 1 location(s) · University of Pennsylvania · NCT06788249A Phase 2 Study to Assess the Safety of EI-1071 and the Effects of EI-1071 on Neuroinflammation in Alzheimer's Disease P
Phase 2 · 2 location(s) · Elixiron Immunotherapeutics Inc. · NCT06745583Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Major De
Phase 3 · 3 location(s) · Khyber Medical University Peshawar · NCT07703722Right-sided 1-Hz Repetitive Transcranial Magnetic Stimulation (rTMS) Versus Left-sided Intermittent Theta Burst Stimulat
Phase 4 · 2 location(s) · Region Örebro County · NCT07026461Regulation of Affect and Physiology in Depression
Phase 2 · 1 location(s) · University of Southern California · NCT06345859Reward Processing and Depressive Subtypes: Identifying Neural Biotypes
Phase N/A · 1 location(s) · San Francisco Veterans Affairs Medical Center · NCT06080646Precision Medicine in the Depression Treatment
Phase N/A · 1 location(s) · Rigshospitalet, Denmark · NCT0561655940 Hz Light Neurostimulation for Patients With Depression (FELIX)
NA · 1 location(s) · Klaus Martiny · NCT05680220tDCS: Sleep to Mood in Depression (S2M-D)
NA · 1 location(s) · NYU Langone Health · NCT07572526Choline to Improve Malnutrition and Enhance Cognition
NA · 10 location(s) · Washington University School of Medicine · NCT06154174A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms
Phase 4 · 40 location(s) · Axsome Therapeutics, Inc. · NCT06223880In Vivo Cortical Excitability Modulation in Major Depressive Disorder
Phase N/A · 1 location(s) · Fundacao Champalimaud · NCT05441969
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This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.