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Study identifier: NCT07745361 Synced from ClinicalTrials.gov · August 04, 2026
● Recruiting

Study of Oral MRT-2359 With Apalutamide in Prostate Cancer

Condition: Castration-Resistant Prostate Cancer (CRPC) · Castration-Resistant Prostate Cancer · Prostate Cancer  ·  Sponsor: Monte Rosa Therapeutics, Inc

PhasePhase 2
Planned participants25
Who can joinMale, 18 Years to no upper limit
Healthy volunteersNo

About this study

This Phase 2, open-label, multicenter study is conducted in patients with castration-resistant prostate cancer. Patients in this study receive MRT-2359, an investigational oral medicine, in combination with apalutamide, an oral medicine used to treat prostate cancer. The main purpose of the study is to assess whether this treatment combination can lower prostate-specific antigen (PSA) The study will also evaluate the safety and tolerability of the treatment combination and assess additional measures of anti-tumor activity.

This description comes directly from the study's public registry record.

Talk to the study team

Monte Rosa Therapeutics Sponsor  ·  617-865-4792  ·  MRT-2359-002StudyTeam@monterosatx.com

Always discuss trial participation with your own doctor first.

Locations (14)

START Los AngelesLos Angeles, California, United StatesRecruiting
Hoag Memorial Hospital PresbyterianNewport Beach, California, United StatesNot Yet Recruiting
Rocky Mountain Cancer CenterColorado Springs, Colorado, United StatesNot Yet Recruiting
Kansas University Cancer CenterKansas City, Kansas, United StatesNot Yet Recruiting
University of Maryland Greenebaum Cancer CenterBaltimore, Maryland, United StatesNot Yet Recruiting
Henry FordNovi, Michigan, United StatesNot Yet Recruiting
XCancer OmahaOmaha, Nebraska, United StatesNot Yet Recruiting
START New JerseyEast Brunswick, New Jersey, United StatesRecruiting
Levine Cancer InstituteCharlotte, North Carolina, United StatesNot Yet Recruiting
Lancaster UrologyLancaster, Pennsylvania, United StatesNot Yet Recruiting
Sarah Cannon Research InstituteNashville, Tennessee, United StatesNot Yet Recruiting
START Mountain RegionWest Valley City, Utah, United StatesRecruiting

+ 2 more locations — full list on the registry record.

Sponsor or site team? See the site landscape for this trial — listed sites, countries, and recruiting-density context.

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