Study identifier: NCT03962543 Synced from ClinicalTrials.gov · August 05, 2026
● Active Not Recruiting

MEK Inhibitor Mirdametinib (PD-0325901) in Patients With Neurofibromatosis Type 1 Associated Plexiform Neurofibromas

Condition: Plexiform Neurofibroma · Neurofibromatosis Type 1 (NF1)  ·  Sponsor: SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany

PhasePhase 2
Planned participants114
Who can joinAll sexes, 2 Years to no upper limit
Healthy volunteersNo

About this study

This study evaluates mirdametinib (PD-0325901) in the treatment of symptomatic inoperable neurofibromatosis type-1 (NF1)-associated plexiform neurofibromas (PNs). All participants will receive mirdametinib (PD-0325901). Eligible participants may continue in a long-term follow-up phase.

This description comes directly from the study's public registry record.

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No contact information is available for this study as per the public registry record.

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Locations (43)

University of Alabama at Birmingham/Children's of AlabamaBirmingham, Alabama, United States
Mayo Clinic ArizonaPhoenix, Arizona, United States
Arkansas Children's HospitalLittle Rock, Arkansas, United States
Children's Hospital Los AngelesLos Angeles, California, United States
University of California, Los Angeles (UCLA)Los Angeles, California, United States
Children's Hospital of Orange CountyOrange, California, United States
University of California - Irvine HealthOrange, California, United States
Lucile Packard Children's Hospital StanfordPalo Alto, California, United States
University of California - DavisSacramento, California, United States
Children's Hospital ColoradoAurora, Colorado, United States
Nemours A. I. duPont Hospital for ChildrenWilmington, Delaware, United States
Children's National HospitalWashington D.C., District of Columbia, United States

+ 31 more locations — full list on the registry record.

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