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Study identifier: NCT03851380 Synced from ClinicalTrials.gov · August 04, 2026
● Completed

Improving Brain Stimulation Through Imaging

Condition: Depression · Depressive Disorder, Treatment-Resistant · COVID Stress  ·  Sponsor: VA Office of Research and Development

PhaseN/A
Planned participants54
Who can joinAll sexes, 18 Years to 89 Years
Healthy volunteersNo

About this study

There are two protocols, one involving rTMS therapy in people with treatment resistant depression and one involving tDCS in people with stress from the COVID 19 pandemic. Clinic-Based rTMS Therapy: Repetitive pulse transcranial magnetic stimulation (rTMS) is a noninvasive treatment that involves stimulating the brain; however, treatment benefit depends on placing a TMS coil in the correct place on the head to reach critical brain regions below. Clinicians typically use scalp-based targeting, a process in which rather than using MRI guidance to target brain regions for stimulation, they use landmarks on the scalp. Several researchers, including the investigators' lab, showed that the current scalp-based targeting techniques do not position stimulation above the correct brain region, and patients fail to respond. The investigators propose to improve clinical scalp-based targeting by comparing it to MRI guided targeting. The most common clinical population receiving rTMS therapy is depressed patients. The investigators' plan is to study the accuracy of certain scalp-based rules in patients with depression. Accurate brain stimulation targeting is critical for effective rTMS therapy. Home-Based Neuromodulation: For participants who are not undergoing rTMS therapy who have COVID-19 distress, we are offering a combined home-based neuromodulation (transcranial electrical stimulation) and focused psychotherapy program dedicated to improving the same outcome measure, quality of life.…

This description comes directly from the study's public registry record.

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No contact information is available for this study as per the public registry record.

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Locations (1)

VA Palo Alto Health Care System, Palo Alto, CAPalo Alto, California, United States

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