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Condition: Lung Cancer With Central Nervous System Metastasis Synced from ClinicalTrials.gov · July 29, 2026

Recruiting studies: Lung Cancer With Central Nervous System Metastasis

Studies currently listed as recruiting on the public registry for this search term. Each page explains the study in plain language, with locations and the study team's contact details. Clinicians: generate a printable list for your patient →

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
Phase 1/Phase 2 · 27 location(s) · Institut de Recherches Internationales Servier · NCT05786924TY-9591 in the Patients With EGFR Mutations in Advanced NSCLC With Brain Metastases
Phase 2 · 1 location(s) · TYK Medicines, Inc · NCT05948813A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain
Phase 2 · 7 location(s) · Memorial Sloan Kettering Cancer Center · NCT05419076WBRT With Hippocampal-avoidance Technique Followed by SRT for Extensive-stage SCLC With Baseline Brain Metastases
Phase 1/Phase 2 · 1 location(s) · Fudan University · NCT06243003Intrathecal Injection Pemetrexed And Bevacizumab in Patients With Leptomeningeal Metastases in NSCLC
Phase 1 · 1 location(s) · Shanghai Chest Hospital · NCT06663306SRT Combined With Anlotinib for the Treatment of Brain Metastases From Non-small Cell Lung Cancer
NA · 1 location(s) · The First People's Hospital of Lianyungang · NCT06476093CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer With Leptomeningeal Disease
NA · 1 location(s) · British Columbia Cancer Agency · NCT052579677T Brain MRI Scan for Micro-brain Metastasis (microBM) Detection for Patients With Small-cell Lung Cancer (SCLC), Who De
Phase N/A · 1 location(s) · University of Missouri-Columbia · NCT07175077Pulsatile High-dose Furmonertinib in EGFR-mutant NSCLC With Leptomeningeal Metastasis
NA · 1 location(s) · Guangzhou University of Traditional Chinese Medicine · NCT07348965A Study of the Safety and Efficacy of Pemetrexed Combined with Nivolumab Via Intraventricular Injection for the Treatmen
Phase 2 · 1 location(s) · Shanghai Cancer Hospital, China · NCT06901817A Study to Evaluate Safety and Efficacy of WSD0922-FU Combo With Osimertinib for NSCLC
Phase 1/Phase 2 · 1 location(s) · Wayshine Biopharm, Inc. · NCT07206498Non-small Cell Lung Cancer With Central Nervous System Metastasis
Phase N/A · 1 location(s) · National Taiwan University Hospital · NCT06026735Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to
Phase 3 · 270 location(s) · NRG Oncology · NCT06500455Improving Osimertinib Exposure and Cost-effectiveness Using Pharmacokinetic Boosting With Cobicistat
Phase 4 · 1 location(s) · Maastricht University Medical Center · NCT05748093Sacituzumab Govitecan and Bevacizumab for NSCLC Brain Metastases
Phase 2 · 3 location(s) · Maastricht University Medical Center · NCT06401824Elimination of PTV Margins Based on MRI-guided Adaptive Stereotactic Radiotherapy for Non-small Cell Lung Cancer With Br
Phase 2 · 1 location(s) · Sun Yat-sen University · NCT06582940Zorifertinib With Osimertinib for NSCLC With Meningeal Progression
Phase 1 · 5 location(s) · Alpha Biopharma (Jiangsu) Co., Ltd. · NCT07361705A Study With Central Nervous System Metastatic EGFR Mutation Positive Non-small Cell Lung Cancer
Phase N/A · 1 location(s) · Hunan Province Tumor Hospital · NCT05991193Hippocampal-Sparing Prophylactic Cranial Irradiation in Pathologically Nodal Positive Non-Small-Cell Lung Cancer
Phase 2/Phase 3 · 1 location(s) · Chang Gung Memorial Hospital · NCT02448992Nitroglycerin Plus Radiotherapy Versus Conventional Radiotherapy in Patients With Lung Cancer.
NA · 1 location(s) · Instituto Nacional de Cancerologia de Mexico · NCT06238882Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer
Phase 1 · 1 location(s) · Sichuan University · NCT06431685Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin
Phase 2 · 1 location(s) · Ayal A. Aizer, MD · NCT07132190Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-
Phase 3 · 58 location(s) · NRG Oncology · NCT06500481Evaluating High-dose Furmonertinib with Bevacizumab and Pemetrexed for EGFRm NSCLC with Leptomeningeal Metastasis
NA · 2 location(s) · Henan Cancer Hospital · NCT06643000Double-Dose Third-Generation EGFR-TKI Plus Bevacizumab and Intrathecal Chemotherapy for Refractory Leptomeningeal Metast
NA · 1 location(s) · Second Affiliated Hospital of Nanchang University · NCT07398599A Real-world Study on the Treatment of Non-small Cell Lung Cancer With Leptomeningeal Metastasis in China
Phase N/A · 2 location(s) · Guangzhou Medical University · NCT06718972Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
Phase 1/Phase 2 · 7 location(s) · Neonc Technologies, Inc. · NCT06047379Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung Cancer
NA · 1 location(s) · Mayo Clinic · NCT05746325A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Efficacy of IDE574 Therapy in Adult Participants Wi
Phase 1 · 11 location(s) · IDEAYA Biosciences · NCT07540572SRS/SRT/Hypo-RT Versus HA-WBRT for No More Than 10 Brain Metastases in SCLC
Phase 3 · 1 location(s) · Cancer Institute and Hospital, Chinese Academy of Medical Sc · NCT06457906
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This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.