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Study identifier: NCT06500455 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

Condition: Anatomic Stage IV Breast Cancer AJCC v8 · Metastatic Breast Carcinoma · Metastatic Digestive System Carcinoma  ·  Sponsor: NRG Oncology

PhasePhase 3
Planned participants269
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This phase III trial compares the effectiveness of fractionated stereotactic radiosurgery (FSRS) to usual care stereotactic radiosurgery (SRS) in treating patients with cancer that has spread from where it first started to the brain. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. FSRS delivers a high dose of radiation to the tumor over 3 treatments. SRS is a type of external radiation therapy that uses special equipment to position the patient and precisely give a single large dose of radiation to a tumor. FSRS may be more effective compared to SRS in treating patients with cancer that has spread to the brain.

This description comes directly from the study's public registry record.

Talk to the study team

Contact details are listed per location below or on the registry record.

Always discuss trial participation with your own doctor first.

Locations (270)

Banner University Medical Center - TucsonTucson, Arizona, United StatesRecruiting
University of Arizona Cancer Center-North CampusTucson, Arizona, United StatesRecruiting
Mercy Hospital Fort SmithFort Smith, Arkansas, United StatesRecruiting
University of Arkansas for Medical SciencesLittle Rock, Arkansas, United StatesRecruiting
Kaiser Permanente-AnaheimAnaheim, California, United StatesRecruiting
Kaiser Permanente-BellflowerBellflower, California, United StatesRecruiting
City of Hope CoronaCorona, California, United StatesRecruiting
City of Hope Comprehensive Cancer CenterDuarte, California, United StatesRecruiting
UC San Diego Health System - EncinitasEncinitas, California, United StatesRecruiting
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory CareIrvine, California, United StatesRecruiting
City of Hope at Irvine LennarIrvine, California, United StatesRecruiting
UC San Diego Moores Cancer CenterLa Jolla, California, United StatesRecruiting

+ 258 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06500455