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Study of Zanubrutinib in Older Patients With Previously Untreated Chronic Lymphocytic Leukemia (CLL)
Condition: Chronic Lymphocytic Leukemia · Small Lymphocytic Lymphoma · Sponsor: The Lymphoma Academic Research Organisation
About this study
This phase II, open-label, multicenter study evaluates zanubrutinib in patients aged 80 years and older with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who require treatment. CLL and SLL are slow-growing blood cancers that mainly affect older adults. Although zanubrutinib is an effective treatment, taking it continuously at the full dose may increase the risk of side effects over time, particularly in elderly patients. The study aims to assess whether a planned reduction in the dose of zanubrutinib after an initial period of treatment can maintain disease control while improving long-term tolerability.
This description comes directly from the study's public registry record.
Talk to the study team
Project management · +33 4 72 66 93 33 · zen-cll@lysarc.org
Always discuss trial participation with your own doctor first.
Locations (17)
| Chu Lyon-Sud | Lyon, Pierre Bénite, France | — |
| Ch Victor Dupouy | Argenteuil, France | — |
| Ch D'Avignon - Hopital Henri Duffaut | Avignon, France | — |
| Ch de La Cote Basque | Bayonne, France | — |
| Institut Bergonie | Bordeaux, France | — |
| Ch Rene Dubos | Cergy-Pontoise, France | — |
| Ch Sud Francilien | Corbeil-Essonnes, France | — |
| Chu de Clermont-Ferrand | Estaing, France | — |
| Chu de Grenoble | Grenoble, France | — |
| Ch de Versailles - Hopital Andre Mignot | Le Chesnay, France | — |
| Ch Du Mans-Centre de Cancerologie de La Sarthe | Le Mans, France | — |
| Hopital Saint Vincent-de-Paul | Lille, France | — |
+ 5 more locations — full list on the registry record.
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