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Efficacy of Lipoic Acid on Chronic Ischemic Heart Failure Patients
Condition: Heart Failure Due to Coronary Artery Disease · Sponsor: Shanghai Zhongshan Hospital
About this study
Chronic heart failure is a clinical condition caused by structural heart disease and is characterized by reduced pumping function, fluid retention, and abnormal activation of neurohormonal systems. It represents the advanced stage of many cardiovascular diseases and remains a major global health challenge. Despite progress in medical and interventional therapies, patients with chronic heart failure continue to experience high rates of death, hospitalization, and long-term disability. Ischemic heart failure, which develops as a result of coronary artery disease and prior myocardial infarction, is the most common form of chronic heart failure. Current treatment strategies, including guideline-directed medical therapy and revascularization procedures, can improve symptoms and outcomes but do not fully address the residual risk of adverse cardiovascular events. Therefore, additional therapeutic approaches are needed to further improve long-term prognosis in this population. Abnormal myocardial energy metabolism is a key pathological feature of heart failure. Mitochondria play a central role in energy production, and impaired mitochondrial function contributes to disease progression. Previous studies by our group have identified mitochondrial aldehyde dehydrogenase 2 (ALDH2) as an important regulator of myocardial metabolic homeostasis and cardiac protection under ischemic and stress conditions. Alpha-lipoic acid is a vitamin B-related compound with antioxidant properties and h…
This description comes directly from the study's public registry record.
Talk to the study team
Aijun Sun · 021-64041990 · sun.aijun@zs-hospital.sh.cn
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Locations (21)
| The First Affiliated Hospital of USTC (Anhui Provincial Hospital) | Hefei, Anhui, China | — |
| Fujian provincial hospital | Fuzhou, Fujian, China | — |
| The First Affiliated Hospital, Sun Yat-sen University | Guangzhou, Guangdong, China | — |
| Luoyang Central Hospital Affiliated to Zhengzhou University | Luoyang, Henan, China | — |
| The First Affiliated Hospital of Zhengzhou University | Zhengzhou, Henan, China | — |
| Zhongda Hospital, Southeast University | Nanjing, Jiangsu, China | — |
| Affiliated Zhongshan Hospital of Dalian University | Dalian, Liaoning, China | — |
| The First Affiliated Hospital of Xi'an Jiaotong University | Xi'an, Shaanxi, China | — |
| Qilu Hospital of Shandong University | Jinan, Shandong, China | — |
| Affiliated Hospital of Jining Medical University | Jining, Shandong, China | — |
| The Affiliated Hospital of Qingdao University | Qingdao, Shandong, China | — |
| Zhongshan Hospital, Fudan University | Shanghai, Shanghai Municipality, China | — |
+ 9 more locations — full list on the registry record.
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