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Study identifier: NCT07716098 Synced from ClinicalTrials.gov · July 28, 2026
● Not Yet Recruiting

A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant Depression

Condition: Depressive Disorder, Treatment-Resistant  ·  Sponsor: Janssen Research & Development, LLC

PhasePhase 3
Planned participants348
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to evaluate how well each individual dose of esketamine (56 milligrams \[mg\] and 84 mg) works when compared with placebo in improving depressive symptoms in participants with treatment resistant depression (individuals with major depressive disorder \[MDD\] who have not responded to at least 2 different antidepressant treatments given at an adequate dose for an adequate duration in the current episode of depression).

This description comes directly from the study's public registry record.

Talk to the study team

Study Contact  ·  844-434-4210  ·  Participate-In-This-Study1@its.jnj.com

Always discuss trial participation with your own doctor first.

Locations (1)

Taipei Medical UniversityTaipei, Taiwan

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Source record: clinicaltrials.gov/study/NCT07716098