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Study identifier: NCT07642908 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Striatal and Extra-Striatal Cholinergic Terminal Density in LRRK2-PD Mutation

Condition: Parkinson Disease  ·  Sponsor: University of Michigan

PhaseN/A
Planned participants15
Who can joinAll sexes, 45 Years to no upper limit
Healthy volunteersNo

About this study

This study explores how a specific genetic mutation of leucine-rich repeat kinase 2 (LRRK2) affects individuals with Parkinson's disease (PD), comparing those with the mutation to others with Parkinson's disease and without the mutation (iPD). Participants will complete positron emission tomography (PET) and magnetic resonance imaging (MRI) brain imaging, cognitive tests, motor tests, sensory tests, and questionnaires. The aims of this study are to compare brain chemicals in LRRK2 PD patients with iPD patients and to correlate brain chemicals with motor and cognitive tests in LRRK2 PD and iPD patients.

This description comes directly from the study's public registry record.

Talk to the study team

Nathan Alexander, BSc  ·  734-998-6894  ·  natealex@med.umich.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of MichiganAnn Arbor, Michigan, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07642908