Condition: Cholangiocarcinoma · Intrahepatic Cholangiocarcinoma · Extrahepatic Cholangiocarcinoma · Sponsor: Beijing Biotech
This example phase 1/2, open-label, biomarker-selected study evaluates EB-HC01, an allogeneic dual-target CARNK product composed of a 1:1 mixture of HER2-CAR-NK and CEACAM5-CAR-NK cells, in adults with unresectable or metastatic cholangiocarcinoma or other biliary tract cancers after standard therapy. Part A determines safety, dose-limiting toxicities (DLTs), and the recommended phase 2 dose (RP2D) after reduced-intensity lymphodepletion. Part B evaluates preliminary anti-tumor activity, CAR-NK persistence, and biomarker-response associations.
This description comes directly from the study's public registry record.
Seni S Lu, Phd · +86 13076790030 · Seni-Lu@beijing-biotech.com
Always discuss trial participation with your own doctor first.
| Peking University Shenzhen Hospital | Shenzhen, Guangdong, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07641036