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Study identifier: NCT07599865 Synced from ClinicalTrials.gov · August 02, 2026
● Recruiting

Periprosthetic Joint Infection Bubble Study

Condition: Periprosthetic Joint Infection (PJI)  ·  Sponsor: Thomas Jefferson University

PhasePhase 2
Planned participants100
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Patients with an infected knee replacement will receive their standard of care surgical treatment of the infection, with and without additional ultrasound microbubble treatment (randomly divided 50/50 in the active and control groups). Subjects in the active group will receive a local bolus injection of antibiotics and ultrasound-active microbubbles within 24 hours of their revision surgery. The fundamental hypothesis is that a decrease in re-infection rates of at least 24% can be achieved in the active group relative to controls.

This description comes directly from the study's public registry record.

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Contact details are listed per location below or on the registry record.

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Locations (3)

Thomas Jefferson University/Rothman InstitutePhiladelphia, Pennsylvania, United StatesRecruiting
University of Pittsburgh Medical Center (UPMC)Pittsburgh, Pennsylvania, United StatesNot Yet Recruiting
UT Southwestern Medical CenterDallas, Texas, United StatesNot Yet Recruiting

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