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Study identifier: NCT07519772 Synced from ClinicalTrials.gov · July 30, 2026
● Recruiting

A Clinical Study of MK-1045 in People With Non-Hodgkin Lymphoma (MK-1045-008)

Condition: Lymphoma, Non-Hodgkin · Lymphoma, Follicular · Lymphoma, Large B-Cell, Diffuse  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 1/Phase 2
Planned participants200
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Researchers are looking for new ways to treat 2 types of non-Hodgkin lymphoma (NHL) called follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). FL is a slow-growing type of NHL. DLBCL is a fast-growing type of NHL. NHL is a cancer in the lymphatic system that causes swollen lymph nodes. The lymphatic system is part of the immune system. In this study, researchers want to learn if MK-1045 can treat FL and DLBCL. MK-1045 is a study treatment that is an immunotherapy, which helps the immune system fight cancer. The goals of this study are to learn how safe MK-1045 is and if people tolerate it. Researchers also want to see if FL and DLBCL respond (the cancer gets smaller or goes away) to treatment.

This description comes directly from the study's public registry record.

Talk to the study team

Toll Free Number  ·  1-888-577-8839  ·  Trialsites@msd.com

Always discuss trial participation with your own doctor first.

Locations (22)

Colorado Blood Cancer Institute ( Site 7000)Denver, Colorado, United StatesRecruiting
SCRI Oncology Partners ( Site 0100)Nashville, Tennessee, United StatesRecruiting
Instituto Alexander Fleming ( Site 1404)Ciudad Autonoma de Buenos Aires, Buenos Aires, ArgentinaRecruiting
Sanatorio Nuestra Senora del Rosario ( Site 1403)Rosario, Santa Fe Province, ArgentinaRecruiting
Beijing Cancer hospital ( Site 1701)Beijing, Beijing Municipality, ChinaRecruiting
Shaare Zedek Medical Center ( Site 0603)Jerusalem, IsraelRecruiting
Haddasah Medical Center ( Site 0600)Jerusalem, IsraelRecruiting
Sheba Medical Center ( Site 0601)Ramat Gan, IsraelRecruiting
Sourasky Medical Center. ( Site 0604)Tel Aviv, IsraelRecruiting
INOC - Istituto Nazionale Oncologico Candiolo ( Site 0701)Candiolo, Piedmont, ItalyRecruiting
Pratia MCM Krakow ( Site 0903)Krakow, Lesser Poland Voivodeship, PolandRecruiting
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworów Układu Chłonnego ( Site 0900)Warsaw, Masovian Voivodeship, PolandRecruiting

+ 10 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07519772