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Study identifier: NCT07509307 Synced from ClinicalTrials.gov · August 02, 2026
● Recruiting

AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

Condition: Obesity · Overweight · Osteoarthritis, Knee  ·  Sponsor: Novo Nordisk A/S

PhasePhase 3
Planned participants400
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study is being done to look at the safety and effect of NNC0487-0111 in people with excess body weight and knee osteoarthritis when compared to placebo. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111, (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.

This description comes directly from the study's public registry record.

Talk to the study team

Novo Nordisk  ·  (+1) 866-867-7178  ·  clinicaltrials@novonordisk.com

Always discuss trial participation with your own doctor first.

Locations (81)

Neighborhood HealthcareEscondido, California, United StatesRecruiting
First Valley Medical GroupLancaster, California, United StatesRecruiting
Desert Oasis HealthcarePalm Springs, California, United StatesRecruiting
Chase Medical Research LLCWaterbury, Connecticut, United StatesRecruiting
Westside Center For Clinical ResearchJacksonville, Florida, United StatesRecruiting
Clinical Neuroscience Solutions, Inc.Jacksonville, Florida, United StatesRecruiting
Advanced Res for Health ImproveNaples, Florida, United StatesRecruiting
Clinical Investigation Spec GurneeGurnee, Illinois, United StatesRecruiting
Evanston Premier Hlthcr ResSkokie, Illinois, United StatesRecruiting
Monroe Biomedical Research, LLCLouisville, Kentucky, United StatesRecruiting
Arcturus Healthcare, PLC.Troy, Michigan, United StatesRecruiting
Clinvest ResearchSpringfield, Missouri, United StatesRecruiting

+ 69 more locations — full list on the registry record.

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