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Study identifier: NCT07497399 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Targeting Agonists of Glucagon-like Peptide-1 Receptor for Multiple Sclerosis

Condition: Multiple Sclerosis  ·  Sponsor: Johns Hopkins University

PhasePhase 2
Planned participants120
Who can joinAll sexes, 18 Years to 60 Years
Healthy volunteersNo

About this study

The goal of this clinical trial is to evaluate if the study drug will reduce brain and retinal atrophy by reducing inflammation and subsequently slowing neurodegeneration in people with Multiple Sclerosis. The main outcome for the trial is change in normalized brain parenchymal volume (nBPV), measured by magnetic resonance imaging (MRI). Researchers will compare outcomes from participants randomized to the study drug, versus participants randomized to placebo, to see if there are signs of slowed neurodegeneration (i.e., reduction in brain and retinal atrophy).

This description comes directly from the study's public registry record.

Talk to the study team

Study Manager  ·  667-306-8153  ·  mvieira4@jh.edu

Always discuss trial participation with your own doctor first.

Locations (2)

Johns Hopkins UniversityBaltimore, Maryland, United StatesRecruiting
Mount Sinai School of MedicineNew York, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07497399