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Study identifier: NCT07467863 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Dual-Target CAR-NK Cells Directed Against MSLN, EGFR, or HER2 in Advanced NSCLC

Condition: Non-Small Cell Lung Cancer · Advanced/Metastatic NSCLC  ·  Sponsor: Beijing Biotech

PhasePhase 1/Phase 2
Planned participants48
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

This is a two-part, biomarker-guided Phase 1/2 study evaluating the safety, feasibility, and preliminary anti-tumor activity of off-the-shelf dual-target CAR-NK cells in participants with advanced or metastatic NSCLC whose tumors co-express at least two of the following antigens: Mesothelin (MSLN), EGFR, and HER2/ERBB2. Participants will receive lymphodepleting chemotherapy followed by infusion of the CAR-NK product matched to their tumor antigen profile. A data-driven interim assessment will be used to select the most suitable construct for expansion.

This description comes directly from the study's public registry record.

Talk to the study team

Seni S Lu, Phd  ·  +86 13076790030  ·  Seni-Lu@beijing-biotech.com

Always discuss trial participation with your own doctor first.

Locations (1)

Peking University Shenzhen HospitalShenzhen, Guangdong, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT07467863