triPle Oral thERapy With Bempedoic Acid vs uSual Care in Early Lipid Management of Patients With acUte coronAry synDromE
Condition: Acute Coronary Syndromes · Secondary Prevention · Lipids · Sponsor: Heart Care Foundation
About this study
Early and intensive LDL-cholesterol (LDL-c) reduction is associated with improved short-term and long-term outcomes. Bempedoic acid is an oral ATP citrate lyase inhibitor that lowers LDL-c upstream of HMG-CoA reductase. When added to maximally tolerated statins, it has demonstrated significant LDL-c reduction and cardiovascular benefit, particularly in statin-intolerant or high-risk patients. However, evidence on early initiation of bempedoic acid during the index ACS hospitalization is currently lacking. The investigators therefore would like to see whether early (pre-discharge) initiation of an oral triple lipid-lowering therapy including bempedoic acid, high-intensity statin (HIS), and ezetimibe is superior to usual care in reducing LDL-c levels at 8 weeks after randomization in patients hospitalized for ACS.
This description comes directly from the study's public registry record.
Talk to the study team
Francesco Orso, MD · +390555101230 · persuade@heartcarefoundation.it
Always discuss trial participation with your own doctor first.
Locations (35)
| Ospedale Miulli - U.O.C. CARDIOLOGIA - UTIC | Acquaviva delle Fonti, Italy | — |
| Ospedale Della Murgia - Fabio Perinei - S.C. Cardiologia-Utic | Altamura, Italy | — |
| Ospedale San Donato - U.O.C Cardiologia | Arezzo, Italy | — |
| Aorn San Giuseppe Moscati - U.O. Cardiologia/Utic 'D. Rotiroti' | Avellino, Italy | — |
| Ospedale San Paolo - Cardiologia-Utic | Bari, Italy | — |
| Ospedale Santo Spirito - SC Cardiologia | Casale Monferrato, Italy | — |
| Azienda Ospedaliera S. Anna E S. Sebastiano - U.O. Cardiologia D'Emergenza Con Utic | Caserta, Italy | — |
| Azienda Ospedaliera Cannizzaro - Uoc Cardiologia | Catania, Italy | — |
| OSPEDALE PIO XI - UOC di Cardiologia | Desio, Italy | — |
| Presidio Ospedaliero "Santa Maria Del Prato" - U.O.C. Di Cardiologia-Utic | Feltre, Italy | — |
| Arcispedale Sant'Anna - U.O. Cardiologia | Ferrara, Italy | — |
| Aou Careggi - Interventistica Cardiologica Strutturale | Florence, Italy | — |
+ 23 more locations — full list on the registry record.
Follow this study
Save your interest here for when the public record changes — results posted, or the study's status changes. Email alerts for this study aren't switched on yet.
We keep this only about this public record, and never email you without alerts being switched on. Want it removed at any time? Email hello@eichor.com. Never medical advice. By subscribing you agree to our Terms of Use and Privacy Policy.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT07440381