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Study identifier: NCT07424833 Synced from ClinicalTrials.gov · August 03, 2026
● Recruiting

A Study of APG-3288 in Relapsed/Refractory Blood Cancers

Condition: Relapsed/Refractory Hematological Malignancies · Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Leukemia (CLL/SLL · Relapsed/Refractory Diffuse Large B-cell Lymphoma (DLBCL; Including Richter Transformation)  ·  Sponsor: Ascentage Pharma Group Inc.

PhasePhase 1
Planned participants180
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a Phase I, multicenter, open-label, two-stage study of APG-3288 monotherapy, aiming to determine the Maximum Tolerated Dose (MTD) and Recommended Phase 2 Dose (RP2D) of APG-3288 administered orally once daily in patients with relapsed/refractory (R/R) hematologic malignancies.

This description comes directly from the study's public registry record.

Talk to the study team

Yifan Zhai, M.D., Ph.D.  ·  18998334688  ·  Yzhai@ascentage.com

Qiwei Chen, M.D.  ·  Qiwei.Chen@ascentage.com

Always discuss trial participation with your own doctor first.

Locations (6)

START Los AngeleLos Angeles, California, United StatesRecruiting
Mayo ClinicJacksonville, Florida, United StatesNot Yet Recruiting
START MidwestGrand Rapids, Michigan, United StatesRecruiting
START New JerseyEast Brunswick, New Jersey, United StatesRecruiting
The University of TX MD Anderson Cancer CenterHouston, Texas, United StatesNot Yet Recruiting
Henan Cancer HospitalZhengzhou, Henan, ChinaRecruiting

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