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Study identifier: NCT07378644 Synced from ClinicalTrials.gov · August 02, 2026
● Recruiting

Study to Evaluate the Pharmacodynamics, Safety and Efficacy of SKY-0515 in Participants With Huntington's Disease

Condition: Huntington Disease  ·  Sponsor: Skyhawk Therapeutics, Inc.

PhasePhase 2/Phase 3
Planned participants400
Who can joinAll sexes, 25 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical trial is to test if the drug SKY-0515, an oral medication, can lower harmful proteins linked to Huntington's Disease (HD) and improve the symptoms of participants with HD. This study includes men and women aged 25 and older who have HD confirmed by genetic testing and meet certain requirements for physical ability and independence.

This description comes directly from the study's public registry record.

Talk to the study team

Study Director, MD  ·  6178580041  ·  sky0515trials@skyhawktx.com

Always discuss trial participation with your own doctor first.

Locations (19)

IADIN (Instituto Argentino de Investigación Neurológica)Buenos Aires, Buenos Aires, ArgentinaNot Yet Recruiting
Buenos Aires British HospitalCABA, Buenos Aires, ArgentinaRecruiting
Instituto Argentino de Investigación NeurológicaCABA, Buenos Aires, ArgentinaRecruiting
CINME Centro de Investigaciones MetabólicasCABA, Buenos Aires, ArgentinaRecruiting
Sanatorio Mater DeiCABA, Buenos Aires, ArgentinaRecruiting
Fundación ScherbovskyMendoza, Mendoza Province, ArgentinaRecruiting
Centro de Pesquisas Clínicas do Hospital das Clínicas da Universidade Federal de Minas Gerais - Filial EBSERHBelo Horizonte, Minas Gerais, BrazilNot Yet Recruiting
Hospital Angelina CaronCampina Grande do Sul, Paraná, BrazilNot Yet Recruiting
PUCPR - Centro de Pesquisa da Pontifícia Universidade Católica do ParanáCuritiba, Paraná, BrazilNot Yet Recruiting
Instituto de Neurologia de CuritibaCuritiba, Paraná, BrazilNot Yet Recruiting
Hospital Universitario Pedro Ernesto (HUPE)Rio de Janeiro, Rio de Janiero, BrazilNot Yet Recruiting
Hospital Universitário Onofre Lopes (HUOL)Natal, Rio Grande do Norte, BrazilNot Yet Recruiting

+ 7 more locations — full list on the registry record.

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