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Study identifier: NCT07284667 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

Condition: Major Depressive Disorder (MDD) · Depressive Disorder, Treatment-Resistant  ·  Sponsor: ACADIA Pharmaceuticals Inc.

PhasePhase 2
Planned participants153
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

The goal of this clinical trial is to learn if ACP-211 can help treat adults with major depressive disorder (MDD) who have not improved with antidepressant therapy (ADT), including those with treatment resistant depression (TRD). The main questions the study aims to answer are: * Does ACP-211 work better than a placebo (a look-alike capsule with no medicine) to reduce symptoms of depression? * What adverse events do participants have when taking ACP-211?

This description comes directly from the study's public registry record.

Talk to the study team

Sandy Filosi  ·  +1(609) 250-6920  ·  sfilosi@ACADIA-Pharm.com

Lori Lykens  ·  +1(609) 250-6917  ·  lori.lykens@acadia-pharm.com

Always discuss trial participation with your own doctor first.

Locations (23)

University of Alabama at BirminghamBirmingham, Alabama, United StatesActive Not Recruiting
Inland Psychiatric Medical GroupChino, California, United StatesRecruiting
Behavioral Research Specialists, LLCGlendale, California, United StatesRecruiting
Kadima Neuropsychiatry InstituteLa Jolla, California, United StatesRecruiting
PNS Clinical Research LLC dba ATP Clinical ResearchOrange, California, United StatesRecruiting
Mountain View Clinical ResearchDenver, Colorado, United StatesRecruiting
The Medici Medical ResearchHollywood, Florida, United StatesRecruiting
Sandhill Research, LLC/DBA Accel Research SitesLargo, Florida, United StatesActive Not Recruiting
Clinical Neuroscience Solutions, Inc.Orlando, Florida, United StatesRecruiting
IPTB Clinical ResearchTampa, Florida, United StatesRecruiting
Neuroscience Research Institute, Inc.West Palm Beach, Florida, United StatesRecruiting
Vitalix Clinical, Inc.Worcester, Massachusetts, United StatesRecruiting

+ 11 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07284667