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Study identifier: NCT07269249 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Real-world Efficacy and Safety of Neoadjuvant Dostarlimab in Patients With dMMR/MSI-H Locally Advanced Rectal Cancer

Condition: Locally Advanced Rectal Cancer (LARC)  ·  Sponsor: National Cancer Institute, Naples

PhaseN/A
Planned participants50
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is an observational, retrospective-prospective, multicentre trial enrolling all patients included in the AIFA monitoring registry of Dostarlimab for the indication in rectal cancer. The aims of the study are to describe the clinical outcomes and safety of patients with dMMR/MSI-H locally advanced rectal cancer (LARC) receiving neoadjuvant dostarlimab in the real-world setting.

This description comes directly from the study's public registry record.

Talk to the study team

Maria Carmela Piccirillo, MD  ·  +39 08117770280  ·  m.piccirillo@istitutotumori.na.it

Piera Gargiulo, MD  ·  +39 081 1777 0279  ·  piera.gargiulo@istitutotumori.na.it

Always discuss trial participation with your own doctor first.

Locations (2)

ASL Napoli 1, Presidio Ospedaliero Ospedale del mare, Oncologia medicaNaples, ItalyNot Yet Recruiting
IRCCS Fondazione G. Pascale, Unità Operativa Complessa Oncologia AddominaleNaples, ItalyRecruiting

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Source record: clinicaltrials.gov/study/NCT07269249