Condition: BRCA1 Mutation · BRCA2 Mutation · Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Subjects who carry mutations in breast cancer susceptibility genes 1 and 2 (BRCA1 and BRCA2 genes) are at higher risk of developing cancers. Despite the cumulative amount of evidence published in the literature in the last two decades, the management of BRCA mutation carriers is still not completely defined. Since the prevalence of the mutation is estimated to be 1:400 - 1:500 individuals, the total number of BRCA mutation carriers should be around 140.000 - 150.000 in the Italian population. It is estimated that 87% of women with BRCA mutations will experience, in their lifetime, a tumor with a genetic origin. About 20% of the 5200 ovarian cancer cases diagnosed each year in Italy has a genetic origin and could potentially be the object of primary prevention. To date, and to the best of our knowledge, a national prospective data collection on women with BRCA mutations has not been yet established.
This description comes directly from the study's public registry record.
Anna Fagotti · +390630157004 · anna.fagotti@policlinicogemelli.it
Always discuss trial participation with your own doctor first.
| Malzoni Research Hospital | Avellino, Italy | Not Yet Recruiting |
| Centro di Riferimento Oncologico IRCCS | Aviano, Italy | Not Yet Recruiting |
| Università degli Studi di Bari "Aldo Moro" | Bari, Italy | Not Yet Recruiting |
| IRCCS Istituto Tumori "Giovanni Paolo II" | Bari, Italy | Recruiting |
| ASST Papa Giovanni XXIII | Bergamo, Italy | Not Yet Recruiting |
| L'Azienda ospedaliera per l'emergenza "Cannizzaro" | Catania, Italy | Not Yet Recruiting |
| Azienda Ospedaliero Santa Croce e Carle | Cuneo, Italy | Not Yet Recruiting |
| Presidio Ospedaliero Umberto I - ASP di Enna | Enna, Italy | Not Yet Recruiting |
| Azienda Ospedaliero Universitaria Careggi, Oncologia Medica Ginecologica | Florence, Italy | Not Yet Recruiting |
| IRCCS Ospedale Policlinico San Martino | Genova, Italy | Not Yet Recruiting |
| Ospedale S. Maria Goretti, Latina | Latina, Italy | Not Yet Recruiting |
| Ospedale del Tigullio Polo di Lavagna - ASL 4 Chiavarese | Lavagna, Italy | Not Yet Recruiting |
+ 28 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07253051