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Study identifier: NCT07227025 Synced from ClinicalTrials.gov · August 03, 2026
● Recruiting

A Study of Amivantamab and Olomorasib Combination Therapy in Participants With Metastatic Non-Small Cell Lung Cancer

Condition: Carcinoma, Non-Small-Cell Lung  ·  Sponsor: Janssen Research & Development, LLC

PhasePhase 1/Phase 2
Planned participants60
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The main purpose of this study is to find out the most suitable dose (recommended phase 2 combination dose \[RP2CD\]) of amivantamab and olomorasib combination therapy and to assess how well the combination slows down or prevents the growth of tumors in participants with KRAS G12C mutant metastatic non-small cell lung cancer (NSCLC: the most common type of lung cancer; metastatic: has spread to other parts of the body; KRAS G12C mutant: mutation \[change\] in the kirsten rat sarcoma viral oncogene homolog \[KRAS\] gene in tumor cells in which glycine \[G\] at position 12 is replaced with cystine \[C\]).

This description comes directly from the study's public registry record.

Talk to the study team

Study Contact  ·  844-434-4210  ·  Participate-In-This-Study1@its.jnj.com

Always discuss trial participation with your own doctor first.

Locations (13)

New York University Langone Medical CenterNew York, New York, United StatesRecruiting
Oncology Consultants Cancer CenterHouston, Texas, United StatesSuspended
Virginia Cancer SpecialistsFairfax, Virginia, United StatesRecruiting
Princess Margaret HospitalToronto, Ontario, CanadaRecruiting
The First Affiliated Hospital Sun Yat sen UniversityGuangzhou, ChinaRecruiting
Harbin medical university cancer hospitalHarbin, ChinaRecruiting
Shanghai East HospitalShanghai, ChinaRecruiting
Severance Hospital Yonsei University Health SystemSeoul, South KoreaRecruiting
Asan Medical CenterSeoul, South KoreaRecruiting
Samsung Medical CenterSeoul, South KoreaRecruiting
Ankara Universitesi Hastaneleri Tibbi Farmakoloji Anabilim Dali Faz 1 Klinik Arastirma MerkeziAnkara, Turkey (Türkiye)Recruiting
Ankara Bilkent Sehir HastanesiÇankaya, Turkey (Türkiye)Recruiting

+ 1 more locations — full list on the registry record.

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