Study identifier: NCT07188558 Synced from ClinicalTrials.gov · August 05, 2026
● Recruiting

A Study to Investigate Ronde-cel Versus Investigator's Choice CD19 CAR T-Cell Therapy

Condition: Large B-cell Lymphoma · Lymphoma, B-Cell · Relapsed Non-Hodgkin Lymphoma  ·  Sponsor: Lyell Immunopharma, Inc.

PhasePhase 3
Planned participants400
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-targeting CD19/CD20 CAR T-cell therapy, with investigator's choice of CD19 CAR T-cell therapy in patients with relapsed or refractory large B-cell lymphoma in the second-line setting.

This description comes directly from the study's public registry record.

Talk to the study team

David Shook, MD  ·  000-000-0000  ·  clinicaltrials@lyell.com

Mary Lessig, MS  ·  000-000-0000  ·  clinicaltrials@lyell.com

Always discuss trial participation with your own doctor first.

Locations (36)

Banner MD Anderson Cancer CenterGilbert, Arizona, United StatesRecruiting
Honor HealthScottsdale, Arizona, United StatesRecruiting
Mayo Clinic ArizonaScottsdale, Arizona, United StatesRecruiting
University of ArkansasLittle Rock, Arkansas, United StatesNot Yet Recruiting
Cedars-Sinai Medical CenterLos Angeles, California, United StatesRecruiting
University of California, Los Angeles (UCLA)Los Angeles, California, United StatesRecruiting
University of California, IrvineOrange, California, United StatesRecruiting
University of ColoradoAurora, Colorado, United StatesRecruiting
Colorado Blood Cancer InstituteDenver, Colorado, United StatesRecruiting
MedStar Georgetown University HospitalWashington D.C., District of Columbia, United StatesNot Yet Recruiting
Mayo Clinic FloridaJacksonville, Florida, United StatesRecruiting
AdventHealthOrlando, Florida, United StatesNot Yet Recruiting

+ 24 more locations — full list on the registry record.

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