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Study identifier: NCT07174908 Synced from ClinicalTrials.gov · July 30, 2026
● Recruiting

A Phase 3 Study of IN10018 in Combination With D-1553 Versus Standard Therapy for First Line Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation

Condition: Non-Small Cell Lung Cancer  ·  Sponsor: InxMed (Shanghai) Co., Ltd.

PhasePhase 3
Planned participants400
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

This is a multicenter, randomized, open-label, phase III clinical study, to evaluate the efficacy and safety of IN10018 in combination with D-1553 as compared to anti-PD-1 monoclonal antibody (mAb) in combination with platinum and pemetrexed as the first-line treatment for the locally advanced or metastatic KRASG12C mutation-positive non-squamous non-small cell lung cancer (NSCLC).

This description comes directly from the study's public registry record.

Talk to the study team

Shu Fang Project Manager, bachelor  ·  86-15933968623  ·  shu.fang@inxmed.com

Jack Zhang Clinical Trial Manager, bachelor  ·  jack.zhang@inxmed.com

Always discuss trial participation with your own doctor first.

Locations (11)

Beijing Cancer HospitalBeijing, Beijing Municipality, ChinaRecruiting
The First Affiliated Hospital, Sun Yat-sen UniversityGuangzhou, Guangdong, ChinaRecruiting
Henan Cancer HospitalZhengzhou, Henan, ChinaRecruiting
The First Affiliated Hospital of Zhengzhou UniversityZhengzhou, Henan, ChinaRecruiting
Union Hospital Tongji Medidcal College Huazhong University of Science and TechnologyWuhan, Hubei, ChinaRecruiting
Hunan Cancer HospitalChangsha, Hunan, ChinaNot Yet Recruiting
Jiangsu Cancer HospitalNanjing, Jiangsu, ChinaRecruiting
First Affiliated Hospital of Gannan Medical UniversityGannan, Jiangxi, ChinaNot Yet Recruiting
The First Affiliated Hospital of Nanchang UniversityNanchang, Jiangxi, ChinaNot Yet Recruiting
Shanghai Chest HospitalShanghai, Shanghai Municipality, ChinaRecruiting
Zhejiang Cancer HospitalHangzhou, Zhejiang, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT07174908