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Study identifier: NCT07058012 Synced from ClinicalTrials.gov · August 01, 2026
● Recruiting

A Phase II Platform Study to Evaluate Treatment With Cemiplimab Monotherapy or Cemiplimab Plus Fianlimab or Other Novel Combinations in Patients With Colorectal Cancer With Minimal Residual Disease Following Definitive Surgery and Chemotherapy (EMPIRE)

Condition: Colo-rectal Cancer  ·  Sponsor: NSABP Foundation Inc

PhasePhase 2
Planned participants79
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The NSABP FC-13 study is being done to determine if using immunotherapies alone or in combination with other drugs will delay or prevent colorectal cancer from coming back in patients with colorectal cancer who are ctDNA-positive after their treatment. Immunotherapeutic drugs (immunotherapies) act on different proteins on the surface of cells of the immune system and trigger the immune system to destroy cancer cells. The drugs being studied in NSABP FC-13 are cemiplimab, fianlimab, and REGN7075.

This description comes directly from the study's public registry record.

Talk to the study team

Department of Site and Study Management (DSSM)  ·  1-800-270-3165  ·  industry.trials@nsabp.org

Always discuss trial participation with your own doctor first.

Locations (9)

University of FloridaGainesville, Florida, United StatesRecruiting
University of Iowa - Holden Comprehensive Cancer CenterIowa City, Iowa, United StatesRecruiting
University of Kansas Cancer CenterKansas City, Kansas, United StatesRecruiting
Missouri BaptistSt Louis, Missouri, United StatesRecruiting
First Health of the CarolinasPinehurst, North Carolina, United StatesRecruiting
Allegheny General HospitalPittsburgh, Pennsylvania, United StatesRecruiting
Ballad Health Cancer Center - KingsportKingsport, Tennessee, United StatesRecruiting
Bon Secours St. Francis Medical CenterMidlothian, Virginia, United StatesRecruiting
Virginia Commonwealth University - MasseyRichmond, Virginia, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07058012