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Study identifier: NCT06968962 Synced from ClinicalTrials.gov · August 03, 2026
● Recruiting

Comparison of Sequential to Initial Combination Therapy in PAH

Condition: Pulmonary Arterial Hypertension (PAH)  ·  Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

PhaseNA
Planned participants376
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

This is a multicenter, randomized, controlled, double-blind, and non-inferiority clinical trial to compare the efficacy of sequential to initial combination therapy in patients with pulmonary arterial hypertension (PAH). Ambrisentan and Tadalafil will be used in the study. Our research hypothesis is that the efficacy of sequential combination therapy in PAH patients is not inferior to the initial combination therapy as the primary efficacy endpoint is the change in 6MWD at month 12 from baseline.

This description comes directly from the study's public registry record.

Talk to the study team

Zongye Cai, MD, PhD  ·  +8618258236820  ·  z.cai@zju.edu.cn

Zexin Chen  ·  +86 15867136069  ·  chenzexin@zju.edu.cn

Always discuss trial participation with your own doctor first.

Locations (1)

The Second Affiliated Hospital, Zhejiang University School of MedicineHangzhou, Zhejiang, ChinaRecruiting

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