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Study identifier: NCT06953726 Synced from ClinicalTrials.gov · August 02, 2026
● Recruiting

Comparing the Safety and Efficacy of Apixaban and Rivaroxaban

Condition: Atrial Fibrillation  ·  Sponsor: VA Office of Research and Development

PhasePhase 4
Planned participants10000
Who can joinAll sexes, 65 Years to no upper limit
Healthy volunteersNo

About this study

* The trial will compare two anticoagulants ("blood thinners") that are currently used in the VA and are considered standard care to prevent strokes in patients with atrial fibrillation. The two most commonly-used anticoagulants will be compared: apixaban (Eliquis) and rivaroxaban (Xarelto). They are considered by many doctors to have similar benefits and risks, but no one knows for sure. * The trial only enrolls patients with a diagnosis of atrial fibrillation ("A Fib") or atrial flutter. Most participants will be age 65 or older, and should already be taking apixaban or rivaroxaban. * The investigators will measure, in about 10,000 VA patients nationally, whether the rates of stroke, major bleeding, or death differ between these two drugs. * The trial will last about 7 years, but after the first prescription, all information will be collected from electronic medical records.

This description comes directly from the study's public registry record.

Talk to the study team

Mustabeen Ashfaq, MS  ·  (857) 364-6026  ·  mustabeen.ashfaq@va.gov

Paul A Monach, MD PhD  ·  (857) 364-5552  ·  Paul.Monach@va.gov

Always discuss trial participation with your own doctor first.

Locations (5)

Miami VA Healthcare System, Miami, FLMiami, Florida, United StatesRecruiting
Boston VA CSP Coordinating CenterBoston, Massachusetts, United StatesRecruiting
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MABoston, Massachusetts, United StatesNot Yet Recruiting
Minneapolis VA Call CenterMinneapolis, Minnesota, United StatesRecruiting
VA Portland Health Care System, Portland, ORPortland, Oregon, United StatesRecruiting

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