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Study identifier: NCT06890884 Synced from ClinicalTrials.gov · August 02, 2026
● Recruiting

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

Condition: Lymphoma, Large B-Cell, Diffuse  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 2
Planned participants594
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Researchers are looking for ways to treat germinal center B-cell-like diffuse large B-cell lymphoma (GCB DLBCL). DLBCL is a fast-growing blood cancer that affects B-cells. GCB is a type of DLBCL that affects young B-cells that are still maturing. The goal of this study is to learn if more people who receive zilovertamab vedotin (MK-2140) and R-CHP have the cancer respond (go away) than those who receive polatuzumab vedotin and R-CHP.

This description comes directly from the study's public registry record.

Talk to the study team

Toll Free Number  ·  1-888-577-8839  ·  Trialsites@msd.com

Always discuss trial participation with your own doctor first.

Locations (139)

Infirmary Cancer Care ( Site 0157)Mobile, Alabama, United StatesRecruiting
Ironwood Cancer & Research Centers ( Site 0204)Chandler, Arizona, United StatesRecruiting
Palo Verde Cancer Specialists ( Site 0105)Glendale, Arizona, United StatesRecruiting
City of Hope - Phoenix ( Site 0202)Goodyear, Arizona, United StatesRecruiting
Genesis Cancer and Blood Institute ( Site 0193)Hot Springs, Arkansas, United StatesRecruiting
Roy and Patricia Disney Family Cancer Center - Providence Saint Joseph Medical Center ( Site 0135)Burbank, California, United StatesRecruiting
City of Hope Comprehensive Cancer Center ( Site 0191)Duarte, California, United StatesRecruiting
Bass Medical Group ( Site 0123)Walnut Creek, California, United StatesRecruiting
Rocky Mountain Cancer Centers (RMCC) ( Site 8001)Aurora, Colorado, United StatesRecruiting
Colorado West Healthcare System-Grand Valley Oncology ( Site 0165)Grand Junction, Colorado, United StatesRecruiting
Medical Oncology Hematology Consultants (MOHC) ( Site 8007)Newark, Delaware, United StatesRecruiting
Georgetown University Medical Center ( Site 0117)Washington D.C., District of Columbia, United StatesRecruiting

+ 127 more locations — full list on the registry record.

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