Comparing Radiation Therapy to Usual Treatment for Patients With High-Risk Bone Metastases That Are Not Causing Pain, PREEMPT Trial
Condition: Metastatic Malignant Neoplasm in the Bone · Metastatic Malignant Solid Neoplasm · Sponsor: NRG Oncology
About this study
This phase III trial compares the effect of adding radiation therapy to usual treatment on the occurrence of bone-related complications in cancer patients with high-risk bone metastases that are not causing symptoms, such as pain (asymptomatic). High-risk bone metastases are defined by their location (including hip, shoulder, long bones, and certain levels of the spine), or size (2 cm or larger). These bone metastases appear to be at higher risk of complications such as fracture, spinal cord compression, and/or pain warranting surgery or radiation treatment. Radiation therapy uses high energy x-rays to kill cancer cells and shrink tumors. The total dose of radiation can be delivered in a single day or divided in smaller doses for up to 5 days of total treatment. Usual treatment for asymptomatic bone metastases may include drugs that prevent bone loss, in addition to the treatment for the primary cancer or observation (which means no treatment until symptoms appear). Evidence has shown that preventative radiation therapy may be effective in lowering the number of bone metastases-related complications, however, it is not known if this approach is superior to usual care. Adding radiation therapy to usual treatment may be more effective in preventing bone-related complications than usual care alone in cancer patients with asymptomatic high-risk bone metastases.
This description comes directly from the study's public registry record.
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No contact information is available for this study as per the public registry record.
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Locations (626)
| Fairbanks Memorial Hospital | Fairbanks, Alaska, United States | — |
| Banner MD Anderson Cancer Center | Gilbert, Arizona, United States | — |
| Cancer Center at Saint Joseph's | Phoenix, Arizona, United States | — |
| Banner-University Medical Center Phoenix | Phoenix, Arizona, United States | — |
| Banner University Medical Center - Tucson | Tucson, Arizona, United States | — |
| University of Arizona Cancer Center-North Campus | Tucson, Arizona, United States | — |
| Kaiser Permanente-Anaheim | Anaheim, California, United States | — |
| Kaiser Permanente-Deer Valley Medical Center | Antioch, California, United States | — |
| Mission Hope Medical Oncology - Arroyo Grande | Arroyo Grande, California, United States | — |
| Sutter Auburn Faith Hospital | Auburn, California, United States | — |
| Sutter Cancer Centers Radiation Oncology Services-Auburn | Auburn, California, United States | — |
| AIS Cancer Center at San Joaquin Community Hospital | Bakersfield, California, United States | — |
+ 614 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06745024