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Study identifier: NCT06717347 Synced from ClinicalTrials.gov · August 02, 2026
● Recruiting

A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)

Condition: Diffuse Large B-Cell Lymphoma  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 3
Planned participants1046
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to evaluate if zilovertamab vedotin with standard treatment can help people live longer without the cancer growing or spreading than people who receive standard treatment alone.

This description comes directly from the study's public registry record.

Talk to the study team

Toll Free Number  ·  1-888-577-8839  ·  Trialsites@msd.com

Always discuss trial participation with your own doctor first.

Locations (268)

USA Mitchell Cancer Institute ( Site 0173)Mobile, Alabama, United StatesRecruiting
Banner MD Anderson Cancer Center ( Site 0165)Gilbert, Arizona, United StatesRecruiting
Banner MD Anderson Cancer Center - University Medical Center Phoenix ( Site 0167)Phoenix, Arizona, United StatesRecruiting
The University of Arizona Cancer Center - North Campus ( Site 0124)Tucson, Arizona, United StatesRecruiting
Providence Medical Foundation-Oncology ( Site 0168)Fullerton, California, United StatesRecruiting
MemorialCare Health System - Long Beach Medical Center ( Site 9559)Long Beach, California, United StatesRecruiting
Cancer Blood and Specialty Clinic ( Site 0109)Los Alamitos, California, United StatesRecruiting
Cedars-Sinai Medical Center ( Site 0115)Los Angeles, California, United StatesRecruiting
Pacific Hematology Oncology Associates ( Site 0131)San Francisco, California, United StatesRecruiting
Lutheran Hospital - Cancer Centers of Colorado ( Site 0180)Golden, Colorado, United StatesRecruiting
Clermont Oncology Center ( Site 0182)Clermont, Florida, United StatesRecruiting
Bioresearch Partner ( Site 0157)Hialeah, Florida, United StatesRecruiting

+ 256 more locations — full list on the registry record.

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