Condition: Sepsis · Bloodstream Infection · Sponsor: Maastricht University Medical Center
Rapid diagnosis of sepsis is crucial for treatment and survival. Currently, blood culture takes 48 hours-5 days to complete. After starting antimicrobial treatment blood culture results are not reliable. As a result, empirical broad spectrum antimicrobial therapy is mostly used. This implies possible antimicrobial over- or under treatment which is associated with increased antimicrobial resistance development. Early identification of the causative pathogen of sepsis will therefore have a major impact on the adequate treatment and reduction of high mortality rates. To date, there is not a single molecular diagnostic test available on the market to detect all putative causative bacterial pathogens of sepsis. In this study, the investigators will develop and validate a completely new molecular sepsis approach based on pathogen DNA detection, as an alternative to culture.
This description comes directly from the study's public registry record.
Anna Wijen, Msc. · +31 626882868 · anna.wijen@maastrichtuniversity.nl
Paul Savelkoul, Prof. Dr. · +31 433876610 · paul.savelkoul@mumc.nl
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| Maastricht University Medical Center | Maastricht, Limburg, Netherlands | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06624618