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Study identifier: NCT06593600 Synced from ClinicalTrials.gov · August 03, 2026
● Completed

Study of Natriuretic Peptide Receptor 1 (NPR1) Antagonist in Adult Patients With Postural Orthostatic Tachycardia Syndrome (POTS)

Condition: Postural Orthostatic Tachycardia Syndrome (POTS)  ·  Sponsor: Regeneron Pharmaceuticals

PhasePhase 2
Planned participants82
Who can joinAll sexes, 18 Years to 55 Years
Healthy volunteersNo

About this study

This study is researching an experimental drug called REGN7544 (called "study drug"). The study is focused on participants with POTS. The aim of the study is to see how safe, tolerable, and effective the study drug is. The study is looking at several other research questions, including: * How the study drug changes heart rate and blood pressure in participants with POTS * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the study drug less effective or could lead to side effects) * How the study drug affects symptoms associated with POTS

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (16)

Mercy Gilbert Medical CenterGilbert, Arizona, United States
North County Neurology AssociatesCarlsbad, California, United States
Stanford UniversityPalo Alto, California, United States
Southern California Heart SpecialistsPasadena, California, United States
Yale UniversityNew Haven, Connecticut, United States
Innovative Research of West Florida, Inc.Clearwater, Florida, United States
Indiana University Health Neuroscience CenterIndianapolis, Indiana, United States
Beth Israel Deaconess Medical CenterBoston, Massachusetts, United States
Mayo ClinicRochester, Minnesota, United States
Saint Luke's MidAmerica Heart InstituteKansas City, Missouri, United States
New York University LangoneNew York, New York, United States
University of Oklahoma Health Sciences CenterOklahoma City, Oklahoma, United States

+ 4 more locations — full list on the registry record.

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