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Study identifier: NCT06588738 Synced from ClinicalTrials.gov · August 05, 2026
● Completed

A Study in Patients With Moderate to Severe Plaque Psoriasis to Evaluate the Efficacy and Safety of ESK-001

Condition: Plaque Psoriasis  ·  Sponsor: Alumis Inc

PhasePhase 3
Planned participants862
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical trial is to learn if ESK-001 works to treat moderate to severe plaque psoriasis. The main questions it aims to answer are: * Does ESK-001 reduce the severity of people's psoriasis? * How safe is ESK-001 in people with moderate to severe plaque psoriasis? The study includes 2 comparators: a placebo control (a 'dummy' tablet that does not contain the medicine ESK-001 but looks just like it) and an active control (apremilast, which is a medicine approved to treat psoriasis). People taking part in this study must be men or women aged at least 18 years and have had plaque psoriasis for at least 6 months, currently moderate to severe. Participants will: * take drug every day for 24 weeks. * visit the clinic for checkups and tests. * fill out questionnaires about their psoriasis, itch severity, and change in quality of life. * be assessed for health issues and side effects, physical examinations, vital signs, heart electrical activity measurements, and psychological health. * provide blood and urine samples.

This description comes directly from the study's public registry record.

Talk to the study team

No contact information is available for this study as per the public registry record.

Always discuss trial participation with your own doctor first.

Locations (124)

Total Skin and Beauty Dermatology Center, PCBirmingham, Alabama, United States
Chandler Clinical TrialsChandler, Arizona, United States
Noble Clinical ResearchTucson, Arizona, United States
Zenith Research Inc.Beverly Hills, California, United States
Raoof MDEncino, California, United States
Long Beach Research InstituteLong Beach, California, United States
Dermatology Research AssociatesLos Angeles, California, United States
Empire Clinical Research - PomonaPomona, California, United States
Integrative Skin Science and ResearchSacramento, California, United States
UC San DiegoSan Diego, California, United States
Southern California Clinical ResearchSanta Ana, California, United States
Clinical Science Institute Dermatology InstituteSanta Monica, California, United States

+ 112 more locations — full list on the registry record.

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