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Study identifier: NCT06556563 Synced from ClinicalTrials.gov · August 03, 2026
● Recruiting

EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma

Condition: Glioblastoma  ·  Sponsor: NovoCure GmbH

PhasePhase 3
Planned participants741
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a multicenter, two-arm, randomized, double-blind, placebo-controlled study of Optune® (Tumor Treating Fields at 200 kHz) together with maintenance Temozolomide (TMZ) chemotherapy agent and pembrolizumab compared to Optune® together with maintenance TMZ and placebo in newly diagnosed Glioblastoma (GBM) patients. The primary objective of the study is to evaluate the Overall Survival (OS).

This description comes directly from the study's public registry record.

Talk to the study team

Uz Stammberger  ·  1-877-678-8611  ·  clinicaltrials@novocure.com

Always discuss trial participation with your own doctor first.

Locations (102)

Mayo Clinic HospitalPhoenix, Arizona, United StatesActive Not Recruiting
University of Southern CaliforniaLos Angeles, California, United StatesActive Not Recruiting
Hoag Memorial Hospital PresbyterianNewport Beach, California, United StatesActive Not Recruiting
Stanford Cancer InstitutePalo Alto, California, United StatesActive Not Recruiting
University of CaliforniaSan Francisco, California, United StatesActive Not Recruiting
MedStar Georgetown University HospitalWashington D.C., District of Columbia, United StatesActive Not Recruiting
UF Health NeuromedicineGainesville, Florida, United StatesActive Not Recruiting
Mayo Clinic - FloridaJacksonville, Florida, United StatesActive Not Recruiting
Miami Cancer InstituteMiami, Florida, United StatesActive Not Recruiting
Moffitt Cancer CenterTampa, Florida, United StatesActive Not Recruiting
Northwestern Memorial HospitalChicago, Illinois, United StatesActive Not Recruiting
University of Kentucky Medical CenterLexington, Kentucky, United StatesActive Not Recruiting

+ 90 more locations — full list on the registry record.

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