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Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease
Condition: Crohn's Disease · Sponsor: AbbVie
About this study
Crohn's disease (CD) is a long-lasting disease that causes severe inflammation (redness, swelling), in the digestive tract, most frequently affecting the bowels. It can cause many different symptoms including belly pain, diarrhea, tiredness, and weight loss. Treatments are available but do not work the same for all patients or may stop working over time. This study will evaluate the effectiveness and adverse events of targeted therapies (TaTs) for adult participants with moderate to severe CD. The medicines assessed in this study are risankizumab, trosunilimab, lutikizumab, and ABBV-8736. When participants join the study, they will be randomized into available study treatment groups. Adult participants with CD will be enrolled. Around 540 participants will be enrolled in the study at approximately 300 sites worldwide. Risankizumab and trosunilimab are given as an injection under the skin or as an infusion into the vein. Lutikizumab is given as an injection under the skin. ABBV-8736 is given as an infusion into the vein. There may be higher treatment burden for participants in this trial compared to their standard of care treatment without participating in this study. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, endoscopies, checking for side effects and completing questionnaires and a daily diary.
This description comes directly from the study's public registry record.
Talk to the study team
ABBVIE CALL CENTER · 844-663-3742 · abbvieclinicaltrials@abbvie.com
Always discuss trial participation with your own doctor first.
Locations (255)
| Digestive Health Specialists /ID# 266216 | Dothan, Alabama, United States | Recruiting |
| East View Medical Research /ID# 270377 | Mobile, Alabama, United States | Recruiting |
| Southern California Res. Ctr /ID# 265549 | Coronado, California, United States | Recruiting |
| UC San Diego Health System /ID# 265565 | La Jolla, California, United States | Recruiting |
| uc davis medical center - patient support services building /ID# 265554 | Sacramento, California, United States | Recruiting |
| Clinical Applications Laboratories - San Diego - 3rd Avenue /ID# 267391 | San Diego, California, United States | Recruiting |
| Peak Gastroenterology Associates - Colorado Springs - North Cascade Avenue /ID# 265557 | Colorado Springs, Colorado, United States | Recruiting |
| Danbury Hospital, Western Connecticut Health Network /ID# 265556 | Danbury, Connecticut, United States | Recruiting |
| Yale University School of Medicine /ID# 266786 | New Haven, Connecticut, United States | Recruiting |
| Novum Research /ID# 278128 | Clermont, Florida, United States | Recruiting |
| University of Florida College of Medicine /ID# 266930 | Gainesville, Florida, United States | Recruiting |
| Nature Coast Clinical Research - Inverness /ID# 265874 | Inverness, Florida, United States | Recruiting |
+ 243 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06548542