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Study identifier: NCT06547489 Synced from ClinicalTrials.gov · August 03, 2026
● Recruiting

Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

Condition: Major Depressive Disorder  ·  Sponsor: Syndeio Biosciences, Inc

PhasePhase 2
Planned participants164
Who can joinAll sexes, 18 Years to 64 Years
Healthy volunteersNo

About this study

The goal of this clinical trial is to learn if zelquistinel works to treat depression in adults. It will also learn about the safety of zelquistinel. The main questions it aims to answer are: Does zelquistinel reduce depression scores in participants compared to participants who take a placebo (a look-alike tablet that contains no zelquistinel)? What medical problems are observed in participants who take zelquistinel? Participants will take one tablet of zelquistinel or placebo every week for 6 weeks. Participants will visit the clinic every week of the 6 week period to have the severity of their depression evaluated.

This description comes directly from the study's public registry record.

Talk to the study team

Karen Raudibaugh  ·  781-786-1545  ·  karen.raudibaugh@syndeio.bio

Kelly Kosko  ·  215-510-6405  ·  kelly.kosko@syndeio.bio

Always discuss trial participation with your own doctor first.

Locations (34)

University of Alabama at BirminghamBirmingham, Alabama, United StatesRecruiting
University of Alabama at Birmingham-HuntsvilleHuntsville, Alabama, United StatesActive Not Recruiting
Wr-Pri, LlcEncino, California, United StatesWithdrawn
Irvine Clinical ResearchIrvine, California, United StatesRecruiting
CalNeuro Research GroupLos Angeles, California, United StatesRecruiting
Pacific Clinical Research Management Group LLCUpland, California, United StatesTerminated
Sunwise Clinical Research LLCWalnut Creek, California, United StatesRecruiting
MCB Clinical Research Centers, Inc.Colorado Springs, Colorado, United StatesRecruiting
Mountain View Clinical ResearchDenver, Colorado, United StatesRecruiting
University of Connecticut School of Medicine Psychiatry DepartmentFarmington, Connecticut, United StatesRecruiting
Clinical Neuroscience Solutions, Inc.Jacksonville, Florida, United StatesRecruiting
D&H Pompano Research Center, LLCMargate, Florida, United StatesRecruiting

+ 22 more locations — full list on the registry record.

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