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Study identifier: NCT06517693 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Safety and Pharmacokinetics Study of PGT121.414.LS Alone and in Combination With VRC07-523LS in Infants Exposed to HIV-1

Condition: HIV-1  ·  Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

PhasePhase 1
Planned participants48
Who can joinAll sexes, N/A to 72 Hours
Healthy volunteersYes

About this study

The purpose of this study is to evaluate the safety and pharmacokinetics (PK) of the potent, broadly neutralizing anti-HIV monoclonal antibodies (mAb) PGT121.414.LS alone and in combination with VRC07-523LS soon after birth in infants exposed to HIV-1.

This description comes directly from the study's public registry record.

Talk to the study team

Emily Brown  ·  919-321-3806  ·  embrown@fhi360.org

Always discuss trial participation with your own doctor first.

Locations (17)

Site 5112, David Geffen School of Medicine at UCLALos Angeles, California, United StatesNot Yet Recruiting
Site 5052, University of Colorado DenverAurora, Colorado, United StatesRecruiting
Site 5051, University of Florida JacksonvilleJacksonville, Florida, United StatesRecruiting
Site 5127, Pediatric Perinatal HIVMiami, Florida, United StatesWithdrawn
Site 5030, Emory University School of MedicineAtlanta, Georgia, United StatesNot Yet Recruiting
Site 5083, Rush University Cook County Hospital ChicagoChicago, Illinois, United StatesNot Yet Recruiting
Site 5092, Johns Hopkins University BaltimoreBaltimore, Maryland, United StatesRecruiting
Site 5114, Bronx-Lebanon Hospital CenterThe Bronx, New York, United StatesRecruiting
Site 5013, Jacobi Medical Center BronxThe Bronx, New York, United StatesNot Yet Recruiting
Site 6501, St. Jude Children's Research HospitalMemphis, Tennessee, United StatesNot Yet Recruiting
Site 5128, Baylor College of Medicine/Texas Children's HospitalHouston, Texas, United StatesRecruiting
Site 5072, Hospital Federal dos Servidores do EstadoRio de Janeiro, BrazilNot Yet Recruiting

+ 5 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06517693