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Study identifier: NCT06496178 Synced from ClinicalTrials.gov · August 02, 2026
● Recruiting

A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients (LiGeR-HN2)

Condition: Head and Neck Squamous Cell Carcinoma  ·  Sponsor: Merus B.V.

PhasePhase 3
Planned participants600
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a phase 3 open-label, randomized, controlled, multicenter study to compare petosemtamab vs investigator's choice monotherapy in HNSCC patients for the second- and third-line treatment of incurable metastatic/recurrent disease.

This description comes directly from the study's public registry record.

Talk to the study team

David Yao, MD  ·  +1 617 401 4499  ·  USenquiries@merus.nl

Eduardo Pennella, MD  ·  +1 617 401 4499  ·  USenquiries@merus.nl

Always discuss trial participation with your own doctor first.

Locations (218)

Site 160Mobile, Alabama, United StatesRecruiting
Site 102Prescott, Arizona, United StatesCompleted
Site 125Scottsdale, Arizona, United StatesRecruiting
Site 82Duarte, California, United StatesRecruiting
Site 25La Jolla, California, United StatesRecruiting
Site 173Orange, California, United StatesRecruiting
Site 28Palo Alto, California, United StatesRecruiting
Site 127Sacramento, California, United StatesRecruiting
Site 46San Francisco, California, United StatesRecruiting
Site 130Lone Tree, Colorado, United StatesRecruiting
Site 104Washington D.C., District of Columbia, United StatesRecruiting
Site 12Fort Myers, Florida, United StatesRecruiting

+ 206 more locations — full list on the registry record.

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