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Study identifier: NCT06465329 Synced from ClinicalTrials.gov · August 02, 2026
● Recruiting

A Study of Cemiplimab Plus Chemotherapy Versus Cemiplimab Plus Chemotherapy Plus Other Cancer Treatments for Adult Patients With Operable Non-Small Cell Lung Cancer (NSCLC)

Condition: Non-Small Cell Lung Cancer  ·  Sponsor: Regeneron Pharmaceuticals

PhasePhase 2
Planned participants120
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will enroll adult participants with early-stage (stage II-IIIB) non-small cell lung cancer for whom surgery is planned. The aim is to find out whether an investigational treatment (consisting of the immunotherapy drug cemiplimab plus chemotherapy plus a third drug) works better than cemiplimab plus chemotherapy without the additional drug. The study is also looking at several other research questions, including: * What are the side effects associated with the investigational treatments in comparison to the control treatment? * Do the investigational treatments or the control treatment have an effect on the type of surgery that is performed? * How much of the study drug(s) are in the blood at a given time? * Does the body make antibodies against the study drug(s) (which could make the drug(s) less effective or could lead to side effects)?

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Trials Administrator  ·  844-734-6643  ·  clinicaltrials@regeneron.com

Always discuss trial participation with your own doctor first.

Locations (50)

University of California IrvineOrange, California, United StatesRecruiting
Orchard Healthcare Research Inc.Skokie, Illinois, United StatesRecruiting
Karmanos Cancer InstituteDetroit, Michigan, United StatesRecruiting
Detroit Clinical Research CenterFarmington Hills, Michigan, United StatesRecruiting
Morristown Medical CenterMorristown, New Jersey, United StatesRecruiting
Rutgers Cancer Institute of New JerseyNew Brunswick, New Jersey, United StatesRecruiting
Oncology Hematology Care Clinical Trials LLCCincinnati, Ohio, United StatesRecruiting
Providence Portland Medical CenterPortland, Oregon, United StatesRecruiting
University Of Nebraska Medical CenterPortland, Oregon, United StatesRecruiting
Lifespan Cancer InstituteProvidence, Rhode Island, United StatesRecruiting
Prairie Lakes Healthcare SystemWatertown, South Dakota, United StatesRecruiting
University of Tennessee Medical CenterKnoxville, Tennessee, United StatesRecruiting

+ 38 more locations — full list on the registry record.

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