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A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20)
Condition: Cervical Cancer · Sponsor: Merck Sharp & Dohme LLC
About this study
This study will have two phases: a sacituzumab tirumotecan safety run-in and a Phase 3 portion. The safety run-in phase will be used to evaluate the efficacy and safety of sacituzumab tirumotecan at the dose for evaluation in the Phase 3 portion. The purpose of this study is to compare the efficacy and safety of sacituzumab tirumotecan versus treatment of physician's choice as second-line treatment for participants with recurrent or metastatic cervical cancer in the Phase 3 portion. The primary study hypotheses are that, in the Phase 3 portion, sacituzumab tirumotecan results in a superior overall survival compared to TPC in participants with high trophoblast cell surface antigen 2 (TROP2) expression level and in all participants.
This description comes directly from the study's public registry record.
Talk to the study team
No contact information is available for this study as per the public registry record.
Always discuss trial participation with your own doctor first.
Locations (240)
| USA Mitchell Cancer Institute-Clinical Trials ( Site 4126) | Mobile, Alabama, United States | — |
| Providence Alaska Medical Center ( Site 4137) | Anchorage, Alaska, United States | — |
| HonorHealth (HH) ( Site 8002) | Phoenix, Arizona, United States | — |
| Arizona Oncology Associates - HOPE ( Site 8001) | Tucson, Arizona, United States | — |
| Moores Cancer Center-Clinical Trials Office - Gynecological Oncology ( Site 4125) | La Jolla, California, United States | — |
| UCLA Hematology/Oncology - Westwood (Building 100)-Department of OBGYN, Division of Gynecologic Onc ( Site 4105) | Los Angeles, California, United States | — |
| Hoag Memorial Hospital Presbyterian ( Site 4104) | Newport Beach, California, United States | — |
| Mount Sinai Braman Comprehensive Cancer Center ( Site 4143) | Miami Beach, Florida, United States | — |
| Advent Health ( Site 4140) | Orlando, Florida, United States | — |
| Florida Cancer Specialists East ( Site 7001) | West Palm Beach, Florida, United States | — |
| Northside Hospital ( Site 4127) | Atlanta, Georgia, United States | — |
| Georgia Cancer Center at Augusta University ( Site 4112) | Augusta, Georgia, United States | — |
+ 228 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06459180