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Study identifier: NCT06419634 Synced from ClinicalTrials.gov · August 03, 2026
● Recruiting

Study of BMS-986497 (ORM-6151) as a Monotherapy, in Double and Triple Combination With Azacitidine and Venetoclax in Participants With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

Condition: Acute Myeloid Leukemia · Myelodysplastic Syndrome  ·  Sponsor: Bristol-Myers Squibb

PhasePhase 1
Planned participants105
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to assess the safety, tolerability, drug levels, drug efficacy and determine the recommended dose of BMS-986497 as a monotherapy, in double combination with Azacitidine and in triple combination with Azacitidine and Venetoclax in participants with relapsed or refractory acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).

This description comes directly from the study's public registry record.

Talk to the study team

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com  ·  855-907-3286  ·  Clinical.Trials@bms.com

First line of the email MUST contain NCT # and Site #.

Always discuss trial participation with your own doctor first.

Locations (16)

Yale-New Haven HospitalNew Haven, Connecticut, United StatesRecruiting
Northwestern Memorial HospitalChicago, Illinois, United StatesRecruiting
Local Institution - 0007Boston, Massachusetts, United StatesWithdrawn
Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting
Washington University School of Medicine, Siteman Cancer CenterSt Louis, Missouri, United StatesRecruiting
John Theurer Cancer Center at Hackensack University Medical CenterHackensack, New Jersey, United StatesRecruiting
Columbia University Irving Medical CenterNew York, New York, United StatesWithdrawn
University of Texas MD Anderson Cancer CenterHouston, Texas, United StatesRecruiting
Local Institution - 0009Fairfax, Virginia, United StatesWithdrawn
Princess Margaret Cancer CentreToronto, Ontario, CanadaRecruiting
Jewish General HospitalMontreal, Quebec, CanadaRecruiting
Local Institution - 0017Marseille, Bouches-du-Rhône, FranceNot Yet Recruiting

+ 4 more locations — full list on the registry record.

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