Condition: Diffuse Large B Cell Lymphoma · Sponsor: University Hospital, Montpellier
CAR-T cell therapy has improved survival in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL R/R). However, only 65% of patients achieve a complete metabolic response after this treatment. To date, there is no predictive test for therapeutic response after injection of CAR-T cells. Recent studies have shown that the level of trogocytosis by immune cells correlates with the persistence of tumor cells in patients with hematological malignancies. Our main objective is to identify a phenotypic "signature" of trogocytosis predictive of therapeutic response 6 months after injection of CAR-T cells for DLBCL.
This description comes directly from the study's public registry record.
Valérie ROUILLE · +33467332645 · v-rouille@chu-montpellier.fr
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| Clinical hematology department, University Hospital | Montpellier, France | Recruiting |
| Clinical Investigation Center, University Hospital | Montpellier, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06352242