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Study identifier: NCT06297278 Synced from ClinicalTrials.gov · July 30, 2026
● Recruiting

Exercise Facilitation of Adolescent Fear Extinction, Frontolimbic Circuitry, and Endocannabinoids

Condition: Adolescence  ·  Sponsor: Wayne State University

PhaseNA
Planned participants174
Who can joinAll sexes, 14 Years to 17 Years
Healthy volunteersYes

About this study

Anxiety disorders commonly begin during adolescence, and are characterized by deficits in the ability to inhibit or extinguish pathological fear. Recent research has provided new understanding of how fear is learned and can be regulated in the adolescent brain, and how the endocannabinoid system shapes these processes; however, these advances have not yet translated into improved therapeutic outcomes for adolescents with anxiety. This study will test whether a behavioral intervention, acute exercise, can help to improve fear regulation by enhancing brain activity and endocannabinoid signaling. This line of research may ultimately lead to more effect treatments for adolescent anxiety, and to new preventive strategies for at-risk youth.

This description comes directly from the study's public registry record.

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Locations (1)

Tolan Park Medical BuildingDetroit, Michigan, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06297278