EICHOR
● Recruiting
Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)
Condition: Prostate Cancer Metastatic · Sponsor: Merck Sharp & Dohme LLC
About this study
This is a phase 3, randomized, open-label study of opevesostat compared to alternative abiraterone acetate or enzalutamide in participants with metastatic castration-resistant prostate cancer (mCRPC) with respect to overall survival (OS) in participants with mCRPC previously treated with next-generation hormonal agent (NHA) and taxane-based chemotherapy. It is hypothesized that opevesostat is superior with respect to OS in androgen receptor ligand binding domain (AR LBD) mutation-negative and -positive participants.
This description comes directly from the study's public registry record.
Talk to the study team
Toll Free Number · 1-888-577-8839 · Trialsites@msd.com
Always discuss trial participation with your own doctor first.
Locations (282)
| University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 0040) | Orange, California, United States | Active Not Recruiting |
| Stanford Cancer Center ( Site 0036) | Palo Alto, California, United States | Recruiting |
| Kaiser Permanente Riverside Medical Center ( Site 0099) | Riverside, California, United States | Recruiting |
| Anschutz Cancer Pavilion ( Site 0046) | Aurora, Colorado, United States | Recruiting |
| University of Colorado Health - Highlands Ranch Hospital ( Site 0111) | Highlands Ranch, Colorado, United States | Recruiting |
| Colorado Clinical Research ( Site 0067) | Lakewood, Colorado, United States | Active Not Recruiting |
| University of Colorado Health - Lone Tree Medical Center ( Site 0112) | Lone Tree, Colorado, United States | Recruiting |
| Yale-New Haven Hospital-Yale Cancer Center ( Site 0064) | New Haven, Connecticut, United States | Recruiting |
| Florida Cancer Specialists - South ( Site 7003) | Fort Myers, Florida, United States | Recruiting |
| Bruce W. Carter Veterans Affairs Medical Center ( Site 0082) | Miami, Florida, United States | Active Not Recruiting |
| University of Miami Hospital and Clinics, Sylvester Cancer Center ( Site 0051) | Miami, Florida, United States | Recruiting |
| University of Illinois at Chicago ( Site 0105) | Chicago, Illinois, United States | Recruiting |
+ 270 more locations — full list on the registry record.
Follow this study
Save your interest here for when the public record changes — results posted, or the study's status changes. Email alerts for this study aren't switched on yet.
We keep this only about this public record, and never email you without alerts being switched on. Want it removed at any time? Email hello@eichor.com. Never medical advice. By subscribing you agree to our Terms of Use and Privacy Policy.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT06136624