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Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib
Condition: Carcinoma, Non-Small-Cell Lung · Sponsor: Janssen Research & Development, LLC
About this study
The purpose of this study is to evaluate whether enhanced dermatologic management can reduce incidence of grade greater than or equal to (\>=) 2 dermatologic adverse events of interest (DAEIs) when compared with standard-of-care skin management and with modified enhanced dermatologic management in participants with locally advanced or metastatic stage IIIB/C-IV epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) treated first-line with amivantamab and lazertinib. The study also includes Expansion cohorts (in 2 different schedules) to evaluate enhanced dermatologic management and early intervention for DAEIs or paronychia, in participants receiving subcutaneous amivantamab and lazertinib. A substudy will enroll participants from Arms A and B who experience specific new-onset or persistent DAEIs (Grade \>=2) during treatment with intravenous (IV) amivantamab and lazertinib. This substudy aims to assess the reactive use of dermatologic treatment strategies in these participants.
This description comes directly from the study's public registry record.
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No contact information is available for this study as per the public registry record.
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Locations (93)
| Ironwood Cancer and Research Center | Chandler, Arizona, United States | — |
| City of Hope | Duarte, California, United States | — |
| Providence Fullerton | Fullerton, California, United States | — |
| Los Angeles Cancer Network | Glendale, California, United States | — |
| City of Hope Seacliff | Huntington Beach, California, United States | — |
| City of Hope Orange County Lennar Foundation Cancer Center | Irvine, California, United States | — |
| City of Hope Long Beach Elm | Long Beach, California, United States | — |
| Cancer and Blood Specialty Clinic | Los Alamitos, California, United States | — |
| Keck Hospital of USC | Los Angeles, California, United States | — |
| USC Norris Oncology Hematology Newport Beach | Newport Beach, California, United States | — |
| Kaiser Permanente Oakland Medical Center | Oakland, California, United States | — |
| Kaiser Permanente Roseville Medical Center | Roseville, California, United States | — |
+ 81 more locations — full list on the registry record.
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